The research (PDF) was based on data from a two year trial conducted at Oxford University. It involved 156 patients, 70 years and older, showing signs of mild cognitive impairment (MCI) believed to be a precursor of full blown Alzheimer's. The initial results published in the journal PLOS ONE in 2010 showed that patients with mild cognitive impairment who took high doses of vitamin B suffered 50 percent less whole brain shrinkage than those who took placebo pills..
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